Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Drug resistance is a major obstacle in the field of pre-clinical and clinical therapeutics. The
development of novel technologies and targeted therapies have yielded new modalities to …

The current inhibitor‐based approach to therapeutics has inherent limitations owing to its
occupancy‐based model: 1) there is a need to maintain high systemic exposure to ensure …

The GI tract is the most exposed organ to proteases, both in physiological and
pathophysiological conditions. For digestive purposes, the lumen of the upper GI tract …

With the increasing world population, demand for industrialization has also increased to
fulfill humans' living standards. Fungi are considered a source of essential constituents to …

Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription,
translation and replication. Aberrant G4 formation and stabilisation is linked to genome …

Multiple studies have confirmed that speckle-type pox virus and zinc finger (POZ) protein
(SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in …

Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …