[HTML][HTML] Risk of herpes zoster associated with JAK inhibitors in immune-mediated inflammatory diseases: a systematic review and network meta-analysis
Q Xu, L He, Y Yin - Frontiers in Pharmacology, 2023 - frontiersin.org
Objective: Janus kinase (JAK) inhibitors are a novel class of drugs that have shown efficacy
in treating immune-mediated inflammatory diseases (IMIDs). However, their safety profile in …
in treating immune-mediated inflammatory diseases (IMIDs). However, their safety profile in …
[HTML][HTML] Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
C Xue, Q Yao, X Gu, Q Shi, X Yuan, Q Chu… - Signal transduction and …, 2023 - nature.com
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
[HTML][HTML] Inhibition of T-cell activity in alopecia areata: Recent developments and new directions
Alopecia areata (AA) is an autoimmune disease that has a complex underlying
immunopathogenesis characterized by nonscarring hair loss ranging from small bald …
immunopathogenesis characterized by nonscarring hair loss ranging from small bald …
[HTML][HTML] SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis
R Pandey, M Bakay, H Hakonarson - Frontiers in immunology, 2023 - frontiersin.org
Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes,
and their development is intricately connected to the disruption of the JAK-STAT signaling …
and their development is intricately connected to the disruption of the JAK-STAT signaling …
[HTML][HTML] Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis
Background The two-way communications along the gut-lung axis influence the immune
function in both gut and lung. However, the shared genetic characteristics of lung function …
function in both gut and lung. However, the shared genetic characteristics of lung function …
[HTML][HTML] The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism
Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging
problems today. COVID-19 in children could be asymptomatic, but can result in a fatal …
problems today. COVID-19 in children could be asymptomatic, but can result in a fatal …
Deciphering the host genetic factors conferring susceptibility to severe COVID-19 using exome sequencing
The COVID-19 pandemic remains a significant public health concern despite the new
vaccines and therapeutics. The clinical course of acute SARS-CoV-2 infection is highly …
vaccines and therapeutics. The clinical course of acute SARS-CoV-2 infection is highly …
Localization and quantification of post-translational modifications of proteins using electron activated dissociation fragmentation on a fast-acquisition time-of-flight …
J Bons, CL Hunter, R Chupalov, J Causon… - Journal of the …, 2023 - ACS Publications
Protein post-translational modifications (PTMs) are crucial and dynamic players in a large
variety of cellular processes and signaling. Proteomic technologies have emerged as the …
variety of cellular processes and signaling. Proteomic technologies have emerged as the …
[HTML][HTML] Emerging Oral Therapies for the Treatment of Psoriasis: A Review of Pipeline Agents
A Drakos, T Torres, R Vender - Pharmaceutics, 2024 - mdpi.com
The introduction of biologic agents for the treatment of psoriasis has revolutionized the
current treatment landscape, targeting cytokines in the interleukin (IL)-23/IL-17 pathway and …
current treatment landscape, targeting cytokines in the interleukin (IL)-23/IL-17 pathway and …
The preclinical discovery and development of deucravacitinib for the treatment of psoriasis
G Coscarella, D Malvaso, M Mannino… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Psoriasis is a chronic inflammatory skin disease that most commonly presents
as plaque psoriasis. The understanding of the pivotal pathogenetic role of the IL-23/IL-17 …
as plaque psoriasis. The understanding of the pivotal pathogenetic role of the IL-23/IL-17 …