Xenotransplantation may be a solution to overcome the shortage of organs for the treatment
of patients with organ failure, but it may be associated with the transmission of porcine …

Background: Xenotransplantation using porcine cells, tissues or organs may be associated
with the transmission of porcine endogenous retroviruses (PERVs). More than 50 viral …

Background: The expression of human complement regulators has been proved as an
effective strategy to overcome hyperacute rejection in discordant xenogeneic organ …

Animals with a targeted disruption of genes can be produced by somatic cell nuclear transfer
(SCNT). However, difficulties in clonal selection of somatic cells with a targeted mutation …

Lactoferrin and lysozyme are 2 glycoproteins with great antimicrobial activity, being part of
the nonspecific defensive system of human milk, though their use in commercial products is …

Regeneration therapy can be classified into three categories. The first category, in vitro
regeneration therapy, makes use of transplanted cultured cells, including embryonic stem …

Intracytoplasmic sperm injection (ICSI)-mediated gene transfer has recently been shown to
be an effective technique for producing transgenic pigs; however, the types of sperm …

Pigs seem to be the answer to worldwide organ donor shortage. Porcine skin may also be
applied as a dressing for severe burns. Genetic modifications of donor animals enable …

The invention relates to methods of selecting and maintaining a population of pigs having a
low copy number of porcine endogenous retrovirus, and the use of Such pigs as a source of …

Background There might be much benefit in xenotransplantation, however, the risk of
infections across species barriers remains, especially porcine endogenous retrovirus …