The application of fluorescein sodium for the resection of medulloblastoma

Z Chen, X Zhang, F Lin, C Li, J Jin, Z Zhou… - Journal of Neuro …, 2022 - Springer
Introduction Surgical resection of medulloblastoma (MB) remains a challenge. At present, a
variety of tracers have been used for intraoperative tumor visualization. However, there are …

Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors

MT Erkkilä, D Reichert, J Gesperger, B Kiesel… - Scientific Reports, 2020 - nature.com
Maximal safe tumor resection remains the key prognostic factor for improved prognosis in
brain tumor patients. Despite 5-aminolevulinic acid-based fluorescence guidance the …

Intraoperative fluorescence diagnosis in the brain: a systematic review and suggestions for future standards on reporting diagnostic accuracy and clinical utility

W Stummer, R Koch, RD Valle, DW Roberts… - Acta …, 2019 - Springer
Background Surgery for gliomas is often confounded by difficulties in distinguishing tumor
from surrounding normal brain. For better discrimination, intraoperative optical imaging …

Sodium fluorescein facilitates guided sampling of diagnostic tumor tissue in nonenhancing gliomas

SG Bowden, JA Neira, BJA Gill, TH Ung… - …, 2018 - journals.lww.com
BACKGROUND Accurate tissue sampling in nonenhancing (NE) gliomas is a unique
surgical challenge due to their intratumoral histological heterogeneity and absence of …

Fluorescence guided resection and glioblastoma in 2015: A review

HA Leroy, M Vermandel, JP Lejeune… - Lasers in surgery …, 2015 - Wiley Online Library
High‐grade gliomas represent a widely heterogeneous group of tumors, the most frequent of
which is glioblastoma multiforme. Its annual incidence has risen over the last decades …

Development and validation of a triple-LED surgical loupe device for fluorescence-guided resections with 5-ALA

ES Molina, SJ Hellwig, A Walke, A Jeibmann… - Journal of …, 2021 - thejns.org
OBJECTIVE Fluorescence-guided resections performed using 5-aminolevulinic acid (5-ALA)
have been studied extensively using the BLUE400 system. The authors introduce a triple …

With a little help from my friends: the role of intraoperative fluorescent dyes in the surgical management of high-grade gliomas

R Maugeri, A Villa, M Pino, A Imperato, GR Giammalva… - Brain Sciences, 2018 - mdpi.com
High-grade gliomas (HGGs) are the most frequent primary malignant brain tumors in adults,
which lead to death within two years of diagnosis. Maximal safe resection of malignant …

5-ALA-guided tumor resection during awake speech mapping in gliomas located in eloquent speech areas: Single-center experience

SA Goryaynov, SB Buklina, IV Khapov… - Frontiers in …, 2022 - frontiersin.org
Background Achieving maximal functionally safe resection of gliomas located within the
eloquent speech areas is challenging, and there is a lack of literature on the combined use …

Introduction of a standardized multimodality image protocol for navigation-guided surgery of suspected low-grade gliomas

A Mert, B Kiesel, A Wöhrer, M Martínez-Moreno… - Neurosurgical …, 2015 - thejns.org
OBJECT Surgery of suspected low-grade gliomas (LGGs) poses a special challenge for
neurosurgeons due to their diffusely infiltrative growth and histopathological heterogeneity …

Navigated 3D–ultrasound versus conventional neuronavigation during awake resections of eloquent low-grade gliomas: a comparative study at a single institution

A Šteňo, V Hollý, P Mendel, V Šteňová, Ľ Petričková… - Acta …, 2018 - Springer
Background The data showing usefulness of navigated 3D–ultrasound (3DUS) during
awake resections of eloquent gliomas are sparse. Results of surgeries performed using …