The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted
homeostatic regulator, which influences a wide-variety of physiological processes all over …

Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Though there is limited research confirming the purported topical benefits of cannabinoids, it
is certain that cutaneous biology is modulated by the human endocannabinoid system …

Itch and pain are distinct unpleasant sensations that can be triggered from the same
receptive fields in the skin, raising the question of how pruriception and nociception are …

Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca 2+-permeable
cation channel that serves as one of the primary sensors of environmental irritants and …

The TRPV3 channel plays vital roles in skin physiology. Dysfunction of TRPV3 causes skin
diseases, including Olmsted syndrome. However, the lack of potent and selective inhibitors …

Transient Receptor Potential (TRP) channels are multifunctional sensory molecules that are
abundant in the skin and are involved in the sensory pathways of itch, pain, and …

Medical marijuana is becoming widely available to patients in the United States, and with
recreational marijuana now legalized in many states, patient interest is on the rise. The …

Itch sensation provokes the scratch reflex to protect us from harmful stimuli in the skin.
Although scratching transiently relieves acute itch through activation of mechanoreceptors, it …