[HTML][HTML] Nanopore technology and its applications in gene sequencing

B Lin, J Hui, H Mao - Biosensors, 2021 - mdpi.com
In recent years, nanopore technology has become increasingly important in the field of life
science and biomedical research. By embedding a nano-scale hole in a thin membrane and …

Cancer biomarker detection: recent achievements and challenges

L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

Recent progress in solid‐state nanopores

K Lee, KB Park, HJ Kim, JS Yu, H Chae… - Advanced …, 2018 - Wiley Online Library
The solid‐state nanopore has attracted much attention as a next‐generation DNA
sequencing tool or a single‐molecule biosensor platform with its high sensitivity of …

Detection and mapping of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore MspA

AH Laszlo, IM Derrington… - Proceedings of the …, 2013 - National Acad Sciences
Precise and efficient mapping of epigenetic markers on DNA may become an important
clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in …

Slow DNA transport through nanopores in hafnium oxide membranes

J Larkin, R Henley, DC Bell, T Cohen-Karni… - ACS …, 2013 - ACS Publications
We present a study of double-and single-stranded DNA transport through nanopores
fabricated in ultrathin (2–7 nm thick) freestanding hafnium oxide (HfO2) membranes. The …

Oxford Nanopore sequencing: new opportunities for plant genomics?

K Dumschott, MHW Schmidt, HS Chawla… - Journal of …, 2020 - academic.oup.com
DNA sequencing was dominated by Sanger's chain termination method until the mid-2000s,
when it was progressively supplanted by new sequencing technologies that can generate …

Optoelectronic control of surface charge and translocation dynamics in solid-state nanopores

N Di Fiori, A Squires, D Bar, T Gilboa… - Nature …, 2013 - nature.com
Nanopores can be used to detect and analyse biomolecules. However, controlling the
translocation speed of molecules through a pore is difficult, which limits the wider application …

Electroosmotic trap against the electrophoretic force near a protein nanopore reveals peptide dynamics during capture and translocation

A Asandei, I Schiopu, M Chinappi, CH Seo… - … applied materials & …, 2016 - ACS Publications
We report on the ability to control the dynamics of a single peptide capture and passage
across a voltage-biased, α-hemolysin nanopore (α-HL), under conditions that the …

Challenges in DNA motion control and sequence readout using nanopore devices

S Carson, M Wanunu - Nanotechnology, 2015 - iopscience.iop.org
Nanopores are being hailed as a potential next-generation DNA sequencer that could
provide cheap, high-throughput DNA analysis. In this review we present a detailed summary …

[HTML][HTML] Smooth DNA transport through a narrowed pore geometry

S Carson, J Wilson, A Aksimentiev, M Wanunu - Biophysical journal, 2014 - cell.com
Voltage-driven transport of double-stranded DNA through nanoscale pores holds much
potential for applications in quantitative molecular biology and biotechnology, yet the …