Endothelin peptides in brain diseases

XJ Nie, Y Olsson - Reviews in the Neurosciences, 1996 - degruyter.com
Endothelin Peptides in Brain Diseases Page 1 © Freund Publishing House Ltd., London
Reviews in the Neurosciences, 7, 177-186 (1996) Endothelin Peptides in Brain Diseases Xiao …

Endothelin levels increase in rat focal and global ischemia

FC Barone, MYT Globus, WJ Price… - Journal of Cerebral …, 1994 - journals.sagepub.com
Endothelin-1, a peptide exhibiting extremely potent cerebral vasoactive properties, is
elevated in the cerebrospinal fluid after hemorrhagic stroke and implicated in cerebral …

Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat

K Fuxe, N Kurosawa, A Cintra, Å Hallström… - Experimental brain …, 1992 - Springer
The present study examines the possibility that lesions induced by intrastriatal injections of
endothelin-1 (ET-1, 0.43 nmol/0.5 µl) are ischemic in nature due to a vasoconstriction of the …

Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors

N Ishikawa, M Takemura, Y Koyama… - European Journal of …, 1997 - Wiley Online Library
The effects of endothelin (ET)‐3 and an ETB receptor agonist on astrocytic activation in rat
caudate putamen were examined by an immunohistochemical staining of glial fibrillary …

NMDA-and endothelin-1-induced increases in blood-brain barrier permeability quantitated with Lucifer yellow

RD Miller, NT Monsul, JR Vender… - Journal of the neurological …, 1996 - Elsevier
At 48 h following intrastriatal injection of N-methyl-d-aspartate (NMDA; 100 nmol/μl) or
endothelin-1 (ET-1; 143 pmol/μl), significant increases in brain penetration of the highly …

Loss of immunoreactivity for glial fibrillary acidic protein (GFAP) in astrocytes as a marker for profound tissue damage in substantia nigra and basal cortical areas after …

R Schmidt‐Kastner, M Ingvar - Glia, 1994 - Wiley Online Library
Status epilepticus induced by pilocarpine in rats induces massive tissue damage comprising
neurons and astrocytes (incomplete infarction) in substantia nigra pars reticulata (SNR) and …

On the cellular localization and distribution of carbonic anhydrase II immunoreactivity in the rat brain

LF Agnati, B Tinner, WA Staines, K Väänänen, K Fuxe - Brain research, 1995 - Elsevier
Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to
wide spread systems of oligodendrocytes and restricted astroglia populations, involving both …

Evidence for a preventive action of the vigilance-promoting drug modafinil against striatal ischemic injury induced by endothelin-1 in the rat

A Ueki, L Rosen, B Andbjer, LF Agnati… - Experimental brain …, 1993 - Springer
We have studied the ability of the vigilance-promoting drug modafinil to counteract the
ischemic lesion produced by a unilateral microinjection of endothelin-1 (ET-1) in the …

The vigilance-promoting drug modafinil counteracts the reduction of tyrosine hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons …

A Ueki, L Rosen, B Andbjer, UB Finnman… - Experimental brain …, 1993 - Springer
We studied the ability of the vigilance-promoting drug modafinil to modulate the anterograde
and retrograde changes in tyrosine hydroxylase (TH) immunoreactivity and in dopamine …

Endothelin-1 exacerbates focal cerebral ischemia without exerting neurotoxic action in vitro

R Nikolov, A Rami, J Krieglstein - European Journal of Pharmacology …, 1993 - Elsevier
In a model of focal cerebral ischemia in mice, intracisternal injection of 5 and 10 pmol/mouse
endothelin-1 significantly increased the infarcted surface area by 15.5% and by 23.5 …