PM2. 5 exposure and asthma development: the key role of oxidative stress

K Liu, S Hua, L Song - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
Oxidative stress is defined as the imbalance between reactive oxygen species (ROS)
production and the endogenous antioxidant defense system, leading to cellular damage …

[HTML][HTML] Pyroptosis in inflammation-related respiratory disease

Y Feng, M Li, X Yangzhong, X Zhang, A Zu… - Journal of physiology …, 2022 - Springer
Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by
the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing …

[HTML][HTML] Lung cancer risk prediction with machine learning models

E Dritsas, M Trigka - Big Data and Cognitive Computing, 2022 - mdpi.com
The lungs are the center of breath control and ensure that every cell in the body receives
oxygen. At the same time, they filter the air to prevent the entry of useless substances and …

[HTML][HTML] Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets

C Pelaia, E Heffler, C Crimi, A Maglio… - Frontiers in …, 2022 - frontiersin.org
Interleukins (IL)-4 and-13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …

Extensive review on the role of machine learning for multifactorial genetic disorders prediction

DD Solomon, Sonia, K Kumar, K Kanwar, S Iyer… - … Methods in Engineering, 2024 - Springer
The culture of employing machine learning driven assistance and decision making is
currently adopted by a variety of industries. Artificial intelligence encompasses a wide range …

[HTML][HTML] Molecular targets for biological therapies of severe asthma

C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …

[HTML][HTML] Global trends in the incidence and mortality of asthma from 1990 to 2019: An age-period-cohort analysis using the global burden of disease study 2019

Y Cao, S Chen, X Chen, W Zou, Z Liu, Y Wu… - Frontiers in Public …, 2022 - frontiersin.org
Background Asthma is a major global health challenge. The global strategic management
and prevention of asthma report has been published, but health system planning for asthma …

[HTML][HTML] Polyamines: their significance for maintaining health and contributing to diseases

M Xuan, X Gu, J Li, D Huang, C Xue, Y He - Cell Communication and …, 2023 - Springer
Polyamines are essential for the growth and proliferation of mammalian cells and are
intimately involved in biological mechanisms such as DNA replication, RNA transcription …

[HTML][HTML] Dietary factors and risk for asthma: A Mendelian randomization analysis

W Yang, Y Yang, L He, M Zhang, S Sun… - Frontiers in …, 2023 - frontiersin.org
Background Previous research has found a link between dietary factors and asthma.
However, few studies have analyzed the relationship between dietary factors and asthma …

[HTML][HTML] Multi-omics profiling approach to asthma: an evolving paradigm

Y Gautam, E Johansson, TB Mersha - Journal of personalized medicine, 2022 - mdpi.com
Asthma is a complex multifactorial and heterogeneous respiratory disease. Although
genetics is a strong risk factor of asthma, external and internal exposures and their …