New treatment options of acute myeloid leukemia (AML) are rapidly emerging. Pre-clinical
models such as ex vivo cultures are extensively used towards the development of novel …

Simple Summary Leukemia is the most common type of childhood malignancy. While the
clinical management of pediatric acute leukemia, especially acute lymphoblastic leukemia …

Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In
cancer, these sirtuins play dichotomous role as tumor suppressor and promoter. Previous …

Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia
(AML), direct implementation in children is challenging due to inherent differences in …

Despite the approval of several drugs for AML, cytarabine is still widely used as a
therapeutic approach. However, 85% of patients show resistance and only 10% overcome …

To gain insights into the idiosyncrasies of CD34+ enriched leukemic stem cells, we
investigated the nature and extent of transcriptional heterogeneity by single-cell sequencing …

Cold atmospheric plasma (CAP) represents a novel onco-therapeutic approach that has
demonstrated its efficacy in many types of tumors. The efficacy of CAP is dose-dependent …

The use of gene expression profiling (GEP) in cancer management is rising, as GEP can be
used for disease classification and diagnosis, tailoring treatment to underlying genetic …

Aim: Transcriptional regulation is actively involved in the onset and progression of various
diseases. This study used the feature-engineering approach model-based quantitative …

Background. Leukemic stem cells (LSCs) play an important role in the pathogenesis of
leukemia. This research attempted to clarify effects of the telomere system on ginsenoside …