High survival rates in adolescent cancer patients have shifted the medical focus to the long-
term outcomes of cancer treatments. Surgery, chemotherapy, and radiation increase the risk …

The most common limitation of anticancer chemotherapy is the injury to normal cells.
Cyclophosphamide, which is one of the most widely used alkylating agents, can cause …

Endometriosis is a common gynecological disorder that causes female infertility. Our recent
research found that excessive oxidative stress in ovaries of endometriosis patients induced …

Ganoderma lucidum polysaccharide peptide (GLPP), is one of the most constituents of
Ganoderma lucidum (G. lucidum) with a wide range of functional activities. The present …

Cyclophosphamide (CTX), a widely used chemotherapeutic agent for cancer treatment, has
been associated with long-term toxicity and detrimental effects on oocytes and ovaries …

Chemotherapy-induced ovarian damage and infertility are significant concerns for women of
childbearing age with cancer; however, the underlying mechanisms are still not fully …

Ovarian tissue has a unique microarchitecture and a complex cellular and molecular
dynamics that are essential for follicular survival and development. Due to this great …

Cytotoxic chemotherapies have been a mainstay of cancer treatment but are associated with
numerous systemic adverse effects, including impacts on fertility and endocrine health …

STUDY QUESTION To what extent and via what mechanism does the concomitant
administration of rapamycin (a follicle activation pathway inhibitor and antitumour agent) and …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …