Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …

The limited clinical efficacy of current symptomatic treatment and minute effect on
progression of Alzheimer's disease has shifted the research focus from single targets …

Abstract Both cholinesterases (AChE and BChE) and kinases, such as GSK-3α/β, are
associated with the pathology of Alzheimer's disease. Two scaffolds, targeting AChE …

A novel series of triazole-based compounds have been designed, synthesised and
evaluated as multi-target-directed ligands (MTDLs) against Alzheimer disease (AD). The …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that has multiple
causes. Therefore, multiple-target-directed ligands (MTDLs), which act on multiple targets …

Alzheimer's disease (AD) is a complex neurological disorder and multiple pathological
factors are believed to be involved in the genesis and progression of the disease. A number …

The multi-targeted organized strategy provides effectual and significant results to cure
progressive neurodegenerative diseases like AD. Treatment for this awful disease is in …

An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in
a series of hybrids (including the hit compound PZ1) based on the framework of the …