The treatment of Melanoma, one of the most aggressive human malignancies, has been
revolutionised by the advent of novel targeted and immuno-therapies. However, methods …

Background Integrins are heterodimeric proteins composed of noncovalently linked ɑ and β
subunits which are essential for a wide range of normal physiology and also play prominent …

Sentinel lymph node biopsy (SLNB) is recommended for patients with> pT1b cutaneous
melanoma, and should be considered and discussed with patients diagnosed with pT1b …

While the development of targeted and immunotherapies for malignant melanoma has
dramatically improved patient outcomes, there remains a need for biomarkers to aid in the …

BACKGROUND Deep transection of invasive melanoma precludes accurate measurement
of Breslow depth, which may affect tumor staging. OBJECTIVE To determine the frequency …

IMPORTANCE—Use of prognostic gene expression profile (GEP) testing in cutaneous
melanoma (CM) is rising despite a lack of endorsement as standard of care. OBJECTIVE …

© Annals of Translational Medicine. All rights reserved. Ann Transl Med 2023; 11 (10): 368|
https://dx. doi. org/10.21037/atm-23-839 confidence interval crosses the threshold of 1 in …

Objective High T cell infiltration in vulvar squamous cell carcinoma (VSCC) is associated
with favorable clinical outcome across molecular subtypes. Here, a more in-depth …

Melanocytic neoplasms constitute some of the most challenging histopathologic entities in
pathology and trigger high levels of diagnostic uncertainty among general practice …

Clinical management of cutaneous melanoma, especially resectable stage III disease, has
rapidly evolved over the past decade, and critical to developing an accurate treatment plan …