In fission yeast, cytokinesis requires a contractile actomyosin ring (CR) coupled to
membrane and septum ingression. Septation proceeds in two phases. In anaphase B, the …

Glucan synthases synthesize glucans, complex polysaccharides that are the major
components in fungal cell walls and division septa. Studying regulation of glucan synthases …

Pmk1, a fission yeast homologue of mammalian ERK MAPK, regulates cell wall integrity,
cytokinesis, RNA granule formation and ion homeostasis. Our screen for vic (viable in the …

Cytokinesis is a complicated yet conserved step of the cell-division cycle that requires the
coordination of multiple proteins and cellular processes. Here we describe a previously …

The two PKC orthologs Pck1 and Pck2 in the fission yeast Schizosaccharomyces pombe
operate in a redundant fashion to control essential functions, including morphogenesis and …

Fission yeast its3-1 mutant is an allele of the essential gene its3+ that encodes a
phosphatidylinositol-4-phosphate 5-kinase (PIP5K) that produces phosphatidylinositol 4, 5 …

Mitogen activated protein kinase (MAPK) signaling pathways execute essential functions in
eukaryotic organisms by transducing extracellular stimuli into adaptive cellular responses. In …

ABSTRACT The Rho GTPase family and their effectors are key regulators involved in many
eukaryotic cell functions related to actin organization and polarity establishment …

Rho GTPases regulate fundamental processes including cell morphology and migration in
various organisms. Guanine nucleotide exchange factor (GEF) has a crucial role in …

The mammalian protein kinase C (PKC) superfamily plays regulatory roles in many dif ferent
cellular processes. However, due to the many members that exist in cells, it is very …