Environmental toxins are harmful substances detrimental to humans. Constant exposure to
these fatal neurotoxins can cause various neurodegenerative disorders. Although …

Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

The central nervous system, once thought to be a site of immunological privilege, has since
been found to harbour immunocompetent cells and to communicate with the peripheral …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

The GABAB receptor agonist, baclofen, is used to treat muscle tightness and cramping
caused by spasticity in a number of disorders including multiple sclerosis (MS), but its …

The GABAB receptors are metabotropic G protein-coupled receptors (GPCRs) that mediate
the actions of the primary inhibitory neurotransmitter, γ-aminobutyric acid (GABA). In the …

Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder
(AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with …

Adult dendritic spines present structural and functional plasticity, which forms the basis of
learning and memory. To provide in vivo evidence of spine plasticity under neurotoxicity, we …

Oxidative decomposition of several biomolecules produces reactive aldehydes. Monoamine
neurotransmitters are enzymatically converted to aldehydes via monoamine oxidase …

Myelination of axons in the neonatal brain is a highly complex process primarily achieved by
oligodendroglial cells (OLs). OLs express receptors for γ‐aminobutyric acid (GABA) which is …