This review extensively reports data from the literature concerning the complex relationships
between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …

The MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons
of vertebrates and invertebrates. How JIP3's interaction with dynein and kinesin-1 …

Neuronal autophagosomes form and engulf cargos at presynaptic sites in the axon and are
then transported to the soma to recycle their cargo. Autophagic vacuoles (AVs) mature en …

Lysosomes robustly accumulate within axonal swellings at Alzheimer's disease (AD)
amyloid plaques. However, the underlying mechanisms and disease relevance of such …

The transport system in cochlear hair cells (HCs) is important for their function, and the
kinesin family of proteins transports numerous cellular cargos via the microtubule network in …

Cancer cell–intrinsic properties caused by oncogenic mutations have been well
characterized; however, how specific oncogenes and tumor suppressors impact the tumor …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

The dependence of neurons on microtubule-based motors for the movement of lysosomes
over long distances raises questions about adaptations that allow neurons to meet these …

Neurodegenerative diseases (NDs) are heterogeneous neurological disorders
characterized by a progressive loss of selected neuronal populations. A significant risk factor …