L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats In Vivo
Peripheral neuropathic pain (PNP) is a major health problem for which effective drug
treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical …
treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical …
[HTML][HTML] Twin peaks? No evidence of bimodal distribution of outcomes in clinical trials of nonsurgical interventions for spinal pain: an exploratory analysis
NE O'Connell, SJ Kamper, ML Stevens, Q Li - The Journal of Pain, 2017 - Elsevier
The presence of bimodal outcome distributions has been used as a justification for
conducting responder analyses, in addition to, or in place of analyses of the mean between …
conducting responder analyses, in addition to, or in place of analyses of the mean between …
Carbonic anhydrase inhibitors for the treatment of neuropathic pain and arthritis
A Nocentini, CT Supuran - Carbonic Anhydrases, 2019 - Elsevier
Carbonic anhydrase inhibitors have long been used as diuretics, topically acting
antiglaucoma agents, systemic anticonvulsants, or for the treatment of altitude sickness …
antiglaucoma agents, systemic anticonvulsants, or for the treatment of altitude sickness …
Prenylflavanones as novel T-type calcium channel blockers useful for pain therapy
HD Nguyen, T Okada, F Sekiguchi… - Natural Product …, 2019 - journals.sagepub.com
Prenylated flavonoids have attracted much attention due to their promising and diverse
bioactivities on multitarget tissues. To the best of our knowledge, our recent studies …
bioactivities on multitarget tissues. To the best of our knowledge, our recent studies …
TGR5 protects against pSNL-induced mechanical allodynia by alleviating neuroinflammation in the injured nerves of male mice
WG Shi, Y Yao, YJ Liang, J Lei, SY Feng, Y Tian… - 2024 - researchsquare.com
Neuropathic pain is a pervasive medical challenge that currently lacks effective treatment
solutions. Molecular changes occurring at the site of peripheral nerve damage contribute to …
solutions. Molecular changes occurring at the site of peripheral nerve damage contribute to …
[HTML][HTML] Pregabalin on Hdac2 and Inpp5f levels in rats with CCI-induced neuropathic pain
L Yuan, T Li, Y Wan, Y Liu… - Experimental and …, 2019 - spandidos-publications.com
Hdac2/Inpp5f on the therapeutic effect of pregabalin on neuropathic pain in chronic
constriction injury (CCI) rats was investigated. A total of 90 healthy SD rats were selected …
constriction injury (CCI) rats was investigated. A total of 90 healthy SD rats were selected …
Alleviation of mechanical stress-induced allodynia by improving blood flow in chronic constriction injury mice
H Ishida, S Saito, A Horie, T Ishikawa - European Journal of Pharmacology, 2019 - Elsevier
Reduced blood flow in the skin is observed in patients with neuropathic pain and in animal
models. The aim of the present study was to elucidate the relationship between reduced skin …
models. The aim of the present study was to elucidate the relationship between reduced skin …
Targeting neuropathic pain: pathobiology, current treatment and peptidomimetics as a new therapeutic opportunity
MC Caroleo, A Brizzi, M De Rosa… - Current Medicinal …, 2020 - ingentaconnect.com
There is a huge need for pharmaceutical agents for the treatment of chronic Neuropathic
Pain (NP), a complex condition where patients can suffer from either hyperalgesia or …
Pain (NP), a complex condition where patients can suffer from either hyperalgesia or …
Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury-induced neuropathy in rats
ZH Wen, NF Chen, HJ Cheng, HM Kuo, CW Feng… - 2023 - researchsquare.com
Neuropathic pain (NP) affects countless people worldwide, but there is no effective
treatment. Histone deacetylases (HDACs) participate in epigenetic modifications, which are …
treatment. Histone deacetylases (HDACs) participate in epigenetic modifications, which are …