Bacterial infectious diseases are one of the leading causes of death worldwide. Even with
the use of multiple antibiotic treatment strategies, 4.95 million people died from drug …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …

The nature of activation signals is essential in determining T cell subset differentiation;
however, the features that determine T cell subset preference acquired during intrathymic …

Regulatory T cells (Tregs) are among the most abundant suppressive cells, which infiltrate
and accumulate in the tumor microenvironment, leading to tumor escape by inducing anergy …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Background Regulatory T cells (Tregs), are a key class of cell types in the immune system. In
the tumor microenvironment (TME), the presence of Tregs has important implications for …

Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

The incomplete removal of T cells that are reactive against self-proteins during their
differentiation in the thymus requires mechanisms of tolerance that prevent their effector …

Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including
discrimination between self-and non-self-antigens, containment of immunopathology, and …

Long-term organ transplant survival remains suboptimal, and life-long immunosuppression
predisposes transplant recipients to an increased risk of infection, malignancy, and kidney …