Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Based on discoveries enabled by new technologies and analysis using novel computational
tools, neuroscience can be re-conceived in terms of information exchange in dense …

Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Neuroinflammation and neurodegeneration may represent two poles of brain pathology.
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …

Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

Vascular cognitive impairment and dementia (VCID) is a major heterogeneous brain
disease caused by multiple factors, and it is the second most common type of dementia in …

Background The tremendous clinical and aetiological diversity among individuals with
autism spectrum disorder (ASD) has been a major obstacle to the development of new …

The role of immune activation in psychiatric disorders has attracted considerable attention
over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the …

The kynurenine pathway of tryptophan degradation generates several neuroactive
compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 …