[HTML][HTML] The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
[HTML][HTML] Old drugs as new treatments for neurodegenerative diseases
F Durães, M Pinto, E Sousa - Pharmaceuticals, 2018 - mdpi.com
Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …
population is becoming older. They manifest themselves through mechanisms that are not …
Polytherapy and targeted cancer drug resistance
N Chatterjee, TG Bivona - Trends in cancer, 2019 - cell.com
A current challenge in cancer treatment is drug resistance. Even the most effective therapies
often fail to produce a complete and durable tumor response and ultimately give rise to …
often fail to produce a complete and durable tumor response and ultimately give rise to …
[HTML][HTML] Plasmin and plasminogen system in the tumor microenvironment: implications for cancer diagnosis, prognosis, and therapy
AG Bharadwaj, RW Holloway, VA Miller, DM Waisman - Cancers, 2021 - mdpi.com
Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …
activation system is utilized by tumor cells in their unrelenting attack on the tissues …
[HTML][HTML] Drug repurposing in cancer therapy: influence of patient's genetic background in breast cancer treatment
Cancer is among the leading causes of death worldwide and it is estimated that in 2040
more than 29 million people will be diagnosed with some type of cancer. The most prevalent …
more than 29 million people will be diagnosed with some type of cancer. The most prevalent …
[HTML][HTML] Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
C Nuevo-Tapioles, F Santacatterina… - Nature …, 2020 - nature.com
Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …
Disulfiram copper nanoparticles prepared with a stabilized metal ion ligand complex method for treating drug-resistant prostate cancers
Disulfiram (DSF), an alcohol-aversion drug, has been explored for cancer treatment. Copper
diethyldithiocarbamate (Cu (DDC) 2) complex formed by DSF and copper ions is a major …
diethyldithiocarbamate (Cu (DDC) 2) complex formed by DSF and copper ions is a major …
[HTML][HTML] Oroxylin A: A promising flavonoid for prevention and treatment of chronic diseases
There have been magnificent advancements in the understanding of molecular mechanisms
of chronic diseases over the past several years, but these diseases continue to be a …
of chronic diseases over the past several years, but these diseases continue to be a …
Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …
cancer deaths throughout the world. The shortfall of affordable and effective first-line …