Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: Repurposing quinacrine for lung cancer therapeutics

B Vaidya, NS Kulkarni, SK Shukla… - International journal of …, 2020 - Elsevier
Drug repurposing is on the rise as an atypical strategy for discovery of new molecules,
involving use of pre-existing molecules for a different therapeutic application than the …

Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology

T Efferth, F Oesch - Seminars in Cancer Biology, 2021 - Elsevier
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …

Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy

M Chen, Z Huang, M Xia, Y Ding, T Shan… - Journal of Controlled …, 2022 - Elsevier
Disulfiram (DSF), a familiar FDA-approved drug used for alcohol withdrawal, has recently
been verified with potent antitumor therapeutic effect by generating Cu (DTC) 2, which is the …

[HTML][HTML] Improving therapy of severe infections through drug repurposing of synergistic combinations

YS Cheng, PR Williamson, W Zheng - Current opinion in pharmacology, 2019 - Elsevier
Highlights•Drug combinations improve efficacy and permit dose reductions of each
drug.•Lowering the dose of combined drugs prevents concentration-associated …

Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects

R Mohi-Ud-Din, A Chawla, P Sharma, PA Mir… - European journal of …, 2023 - Springer
Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …

[HTML][HTML] Anthelmintics for drug repurposing: Opportunities and challenges

SE Alavi, HE Shahmabadi - Saudi Pharmaceutical Journal, 2021 - Elsevier
Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …

Repurposing artemisinin and its derivatives as anticancer drugs: a chance or challenge?

Z Ma, CYN Woon, CG Liu, JT Cheng, M You… - Frontiers in …, 2021 - frontiersin.org
Cancer has become a global health problem, accounting for one out of six deaths. Despite
the recent advances in cancer therapy, there is still an ever-growing need for readily …

Repurposing of chronically used drugs in cancer therapy: a chance to grasp

MA Hijazi, A Gessner, N El-Najjar - Cancers, 2023 - mdpi.com
Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

Current treatments and new possible complementary therapies for epithelial ovarian cancer

MP Garrido, AN Fredes, L Lobos-González… - Biomedicines, 2021 - mdpi.com
Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies. The
late diagnosis is frequent due to the absence of specific symptomatology and the molecular …

Drug repurposing—an emerging strategy in cancer therapeutics

KS Turabi, A Deshmukh, S Paul, D Swami… - Naunyn-Schmiedeberg's …, 2022 - Springer
Cancer is a complex disease affecting millions of people around the world. Despite
advances in surgical and radiation therapy, chemotherapy continues to be an important …