Diuretics are drugs that increase the flow of urine. They are commonly used to treat edema,
hypertension, and heart failure. Typically, the pharmacological group consists of five …

Although a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of
patients do not respond to conventional chemotherapy and experience disease relapse. A …

Membrane proteins play crucial physiological roles in vivo and are the major category of
drug targets for pharmaceuticals. The research on membrane protein is a significant part in …

The role of phospholipid signaling in ovarian cancer is poorly understood. Sphingosine-1-
phosphate (S1P) is a bioactive metabolite of sphingosine that has been associated with …

Drug repurposing is a major field of value-added medicine. It involves investigating and
evaluating existing drugs for new therapeutic purposes that address unmet healthcare …

Disulfiram (DSF) is currently tested in several clinical trials for cancer treatment in
combination with copper (Cu) ions. Usually, DSF and Cu are administered in two separate …

The major obstacle in current cancer therapy is the existence of cancer stem cells (CSCs),
which are responsible for therapeutic resistance and contribute to metastasis and …

Lung cancer has the highest mortality among cancers worldwide due to its high incidence
and lack of the effective cures. We have previously demonstrated that the membrane ion …

In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of
each patient and reduce the toxicity caused by conventional antitumor strategies. It has been …

As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were
designated as the best SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (2′ OMTase) …