The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors.
However, during preclinical studies, metformin concentrations required to induce cell growth …

Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …

Simple Summary Ovarian cancer (OC) is the most common cause of cancer-related deaths
among women worldwide, and its incidence has been increasing and has continued to …

Abstract Cytochrome P450 (P450) enzymes are superfamily of monooxygenases that hold
the utmost diversity of substrate structures and catalytic reaction forms amongst all other …

Drug repurposing has lately received increasing interest in several diseases especially in
cancers, due to its advantages in facilitating the development of new therapeutic strategies …

Adenoid cystic carcinoma (ACC) has a significant patient-population in need of effective
systemic therapy, as no drug is currently approved by the FDA for its management. We …

Skin cancer is one of the most common forms of cancer. Several million people are
estimated to have affected with this condition worldwide. Skin cancer generally includes …

Inflammation is considered an enabling feature of cancer. Besides the persistence of
inflammatory stimuli, also defective mechanisms of resolution can lead to chronic …

p21-Activated kinase 1 (PAK1) is positioned at the nexus of several oncogenic signaling
pathways. Currently, there are no approved inhibitors for disabling the transfer of phosphate …

Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-
grade gliomas are often resistant to therapy and associated with a poor outcome, children …