Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial
Background Single-agent nivolumab showed durable responses, manageable safety, and
promising survival in patients with advanced hepatocellular carcinoma in the phase 1–2 …
promising survival in patients with advanced hepatocellular carcinoma in the phase 1–2 …
Understanding breast cancer as a global health concern
L Wilkinson, T Gathani - The British journal of radiology, 2022 - academic.oup.com
Breast cancer is now the most commonly diagnosed cancer in the world. The most recent
global cancer burden figures estimate that there were 2.26 million incident breast cancer …
global cancer burden figures estimate that there were 2.26 million incident breast cancer …
Sentinel lymph node biopsy vs no axillary surgery in patients with small breast cancer and negative results on ultrasonography of axillary lymph nodes: the SOUND …
OD Gentilini, E Botteri, C Sangalli, V Galimberti… - JAMA …, 2023 - jamanetwork.com
Importance Sentinel lymph node biopsy (SLNB) is the standard of care for axillary node
staging of patients with early breast cancer (BC), but its necessity can be questioned since …
staging of patients with early breast cancer (BC), but its necessity can be questioned since …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
CRISPR in cancer biology and therapy
Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …
transforming biomedical research and providing entirely new approaches for dissecting all …
Radiotheranostics in oncology: current challenges and emerging opportunities
Structural imaging remains an essential component of diagnosis, staging and response
assessment in patients with cancer; however, as clinicians increasingly seek to …
assessment in patients with cancer; however, as clinicians increasingly seek to …
Immunotherapies for hepatocellular carcinoma
JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis …
JM Kocarnik, K Compton, FE Dean, W Fu… - JAMA …, 2022 - jamanetwork.com
Importance The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD
2019) provided systematic estimates of incidence, morbidity, and mortality to inform local …
2019) provided systematic estimates of incidence, morbidity, and mortality to inform local …
[HTML][HTML] Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives
Essential oils (EOs) are volatile and concentrated liquids extracted from different parts of
plants. Bioactive compounds found in EOs, especially terpenes and terpenoids possess a …
plants. Bioactive compounds found in EOs, especially terpenes and terpenoids possess a …
Targeting the tumor stroma for cancer therapy
M Xu, T Zhang, R Xia, Y Wei, X Wei - Molecular Cancer, 2022 - Springer
Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …