HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Comprehensive strategies for the synthesis of isoquinolines: Progress Since 2008

R Gujjarappa, N Vodnala… - Advanced Synthesis & …, 2020 - Wiley Online Library
In the past decades, an enormous number of reports have been dedicated towards the
synthesis of nitrogen containing heterocycles. This immense interest have emerged owing to …

Divergent synthesis of aziridine and imidazolidine frameworks under blue LED irradiation

X Cheng, BG Cai, H Mao, J Lu, L Li, K Wang… - Organic …, 2021 - ACS Publications
We develop a visible light-promoted divergent cycloaddition of α-diazo esters with
hexahydro-1, 3, 5-triazines, leading to a series of aziridine and imidazolidine frameworks in …

Photoredox Catalyst Free, Visible Light‐Promoted C3−H Acylation of Quinoxalin‐2(1H)‐ones in Water

J Lu, XK He, X Cheng, AJ Zhang… - Advanced Synthesis & …, 2020 - Wiley Online Library
A method for the synthesis of 3‐acyl quinoxalin‐2 (1H)‐ones through visible‐light promoted
decarboxylative acylation of α‐oxo‐carboxylic acids with quinoxalin‐2 (1H)‐ones was …

Advances in heterocycle synthesis via [3+ m]-cycloaddition reactions involving an azaoxyallyl cation as the key intermediate

J Xuan, X Cao, X Cheng - Chemical Communications, 2018 - pubs.rsc.org
Heterocyclic compounds are widely found in many natural isolates and medicinally relevant
compounds, as well as some fine chemicals. The development of general and efficient …

[3 + 2]-Cycloaddition of 2H-Azirines with Nitrosoarenes: Visible-Light-Promoted Synthesis of 2,5-Dihydro-1,2,4-oxadiazoles

BG Cai, ZL Chen, GY Xu, J Xuan, WJ Xiao - Organic letters, 2019 - ACS Publications
A formal [3+ 2]-cycloaddition reaction of 2 H-azirines with nitrosoarenes has been achieved
under irradiation by visible light with the assistance of organic dye photoredox catalyst. This …

An overview of the reactions involving azomethine imines over half a decade

A Deepthi, NV Thomas, SL Sruthi - New Journal of Chemistry, 2021 - pubs.rsc.org
Azomethine imines constitute a versatile class of dipoles that are being increasingly used for
the synthesis of biologically relevant heterocycles. This review details the various reactions …

[3+ 2]-Cycloaddition of Azaoxyallyl Cations with Hexahydro-1, 3, 5-triazines: Access to 4-imidazolidinones

D Ji, J Sun - Organic letters, 2018 - ACS Publications
A novel base-promoted [3+ 2] cycloaddition reaction of azaoxyallyl cations with hexahydro-
1, 3, 5-triazines has been developed, affording 4-imidazolidinones in moderate to good …

Base-Mediated [3+ 4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines

J Feng, M Zhou, X Lin, A Lu, X Zhang, M Zhao - Organic letters, 2019 - ACS Publications
A new [3+ 4] cycloaddition of azaoxyallyl cations and anthranils has been achieved for rapid
access to multisubstituted benzodiazepine derivatives. A variety of anthranils and α-halo …

Alkaline-Metal-Promoted Divergent Synthesis of 1-Aminoisoquinolines and Isoquinolines

P Ma, Y Wang, N Ma, J Wang - The Journal of Organic Chemistry, 2024 - ACS Publications
Alkaline-metal-promoted divergent syntheses of 1-aminoisoquinolines and isoquinolines
have been reported involving 2-methylaryl aldehydes, nitriles, and LiN (SiMe3) 2 as …