Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Tumors, wounds, and chronic inflammatory disorders generate a new vascular supply by a
process known as pathological angiogenesis. Whereas formation of the normal blood …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Angiogenesis is crucial for cancer initiation, development and metastasis. Identifying natural
botanicals targeting angiogenesis has been paid much attention for drug discovery in recent …

Herein, we report that vascular endothelial growth factor A (VEGF‐A) engages the PI3K/Akt
pathway by a previously unknown mechanism that involves three tyrosine kinases. Upon …

Investigations over the last decade have established the essential role of growth factors and
their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth …

The recent launch onto the market of five VEGFR inhibitors indicates the therapeutic value of
these agents and the importance of the research in the field of angiogenesis inhibitors for …