Overview of MMP-13 as a promising target for the treatment of osteoarthritis
Q Hu, M Ecker - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …
Inflammation and epigenetic regulation in osteoarthritis
Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …
recognized that there is a major inflammatory component to this disease. In addition to …
The osteological paradox 20 years later: past perspectives, future directions
SN DeWitte, CM Stojanowski - Journal of Archaeological Research, 2015 - Springer
More than 20 years ago, Wood et al.(Curr Anthropol 33: 343–370, 1992) published “The
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …
p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis
D Philipot, D Guérit, D Platano, P Chuchana… - Arthritis research & …, 2014 - Springer
Introduction Recent evidence suggests that tissue accumulation of senescent p16 INK4a-
positive cells during the life span would be deleterious for tissue functions and could be the …
positive cells during the life span would be deleterious for tissue functions and could be the …
Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study
Objective Identify gene expression profiles associated with OA processes in articular
cartilage and determine pathways changing during the disease process. Methods Genome …
cartilage and determine pathways changing during the disease process. Methods Genome …
Identification of long noncoding RNA associated with osteoarthritis in humans
D Xing, J Liang, Y Li, J Lu, H Jia, L Xu… - Orthopaedic …, 2014 - Wiley Online Library
Objective Long noncoding RNAs (lncRNAs) are an important class of genes involved in
various biological functions; however, knowledge about lncRNAs in osteoarthritis (OA) is …
various biological functions; however, knowledge about lncRNAs in osteoarthritis (OA) is …
LncRNAs in osteoarthritis
HM Okuyan, MA Begen - Clinica Chimica Acta, 2022 - Elsevier
Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around
the world. With increasing rates of incidence and prevalence worldwide, OA has become an …
the world. With increasing rates of incidence and prevalence worldwide, OA has become an …
Noncoding RNAs: new regulatory code in chondrocyte apoptosis and autophagy
S Jiang, Y Liu, B Xu, Y Zhang… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Osteoarthritis (OA) is a bone and joint disease characterized by progressive cartilage
degradation. In the face of global trends of population aging, OA is expected to become the …
degradation. In the face of global trends of population aging, OA is expected to become the …
PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice
Objectives Osteoarthritis (OA) is the most common degenerative joint disease in aged
population and its development is significantly influenced by aberrant epigenetic …
population and its development is significantly influenced by aberrant epigenetic …
Emerging roles for long noncoding RNAs in skeletal biology and disease
Normal skeletal development requires tight coordination of transcriptional networks,
signaling pathways, and biomechanical cues, and many of these pathways are dysregulated …
signaling pathways, and biomechanical cues, and many of these pathways are dysregulated …