[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

[HTML][HTML] Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

QS Li, YJ Jia - Neural Regeneration Research, 2023 - journals.lww.com
Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-
dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic …

Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve …

D Liu, G Lu, B Shi, H Ni, J Wang, Y Qiu… - Advanced …, 2023 - Wiley Online Library
Although stem cell‐based therapy is recognized as a promising therapeutic strategy for
spinal cord injury (SCI), its efficacy is greatly limited by local reactive oxygen species (ROS) …

[HTML][HTML] Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Immune response after central nervous system injury

AFM Salvador, J Kipnis - Seminars in immunology, 2022 - Elsevier
Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

Cell development enhanced bionic silk hydrogel on remodeling immune pathogenesis of spinal cord injury via m2 polarization of microglial

J Ling, T Huang, R Wu, C Ma, G Lin… - Advanced Functional …, 2023 - Wiley Online Library
Due to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective
modulation of SCI‐specific inflammatory pathogenesis to achieve desirable therapeutic …

[HTML][HTML] Bone marrow mesenchymal stem cell-derived exosomes accelerate functional recovery after spinal cord injury by promoting the phagocytosis of …

X Sheng, J Zhao, M Li, Y Xu, Y Zhou, J Xu… - Frontiers in cell and …, 2021 - frontiersin.org
Macrophage phagocytosis contributes predominantly to processing central nervous system
(CNS) debris and further facilitates neurological function restoration after CNS injury. The …

[HTML][HTML] Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury

SP Fu, SY Chen, QM Pang, M Zhang, XC Wu… - Frontiers in …, 2022 - frontiersin.org
It is often difficult to regain neurological function following spinal cord injury (SCI).
Neuroinflammation is thought to be responsible for this failure. Regulating the inflammatory …

Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes

Y Xia, R Yang, H Wang, Y Hou, Y Li… - Journal of tissue …, 2022 - journals.sagepub.com
Spinal cord injury (SCI) causes tremendous harm to a patient's physical, mental, and
financial health. Moreover, recovery of SCI is affected by many factors, inflammation is one …