Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation
resulting from various factors. Crohn's disease (CD) and ulcerative colitis (UC) have been …

This review aims to identify in vivo studies investigating the potential of plant substances and
their natural molecules in managing inflammatory bowel disease (IBD). Specifically, the …

Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

Current treatment strategies for inflammatory bowel disease (IBD) seek to alleviate the
undesirable symptoms of the disorder. Despite the higher specificity of newer generation …

Currently, commercialized infliximab (IFX) has rapidly propelled the clinical treatment of IBD,
however, its inherent attributes, such as off-target effects and rapid metabolism, severely …

Ulcerative colitis (UC) is an inflammatory bowel disease that is persistent and nonspecific.
There are several medications available for the treatment of UC. However, conventional UC …

Ulcerative colitis (UC), characterized by syndromes including abdominal pain, bloody stool,
diarrhea, weight loss, and repeated relapse, is a non-specific inflammatory intestinal …

A key signaling channel for the signal transduction of several crucial cytokines implicated in
sepsis is the JAK/STAT system. Once cytokines attach to the proper receptors, JAK kinases …

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal
peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause …