Cardiovascular disease remains the leading cause of death in patients with diabetes.
Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk …

Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …

Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …

Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in patients with
diabetes mellitus and the leading cause of end-stage renal disease in the world. The most …

Background: The vascular complications of diabetes mellitus are the major causes of
morbidity and mortality among people with diabetes. Circular RNAs are a class of …

Although cardiologists have long treated patients with coronary artery disease (CAD) and
concomitant type 2 diabetes mellitus (T2DM), T2DM has traditionally been considered just a …

The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Since the discovery in the 1980s that nitric oxide (NO) is in fact the elusive endothelium-
derived relaxing factor, it has become evident that NO is not only a major cardiovascular …