Bone morphogenetic proteins
T Katagiri, T Watabe - Cold Spring Harbor Perspectives …, 2016 - cshperspectives.cshlp.org
Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …
extracts derived from bone, are now known to play important roles in a wide array of …
Bone morphogenetic protein receptor signal transduction in human disease
MC Gomez‐Puerto, PV Iyengar… - The journal of …, 2019 - Wiley Online Library
Bone morphogenetic proteins (BMPs) are secreted cytokines that were initially discovered
on the basis of their ability to induce bone. Several decades of research have now …
on the basis of their ability to induce bone. Several decades of research have now …
Structural insights into BMP receptors: Specificity, activation and inhibition
D Yadin, P Knaus, TD Mueller - Cytokine & growth factor reviews, 2016 - Elsevier
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β
family (TGFβ), which signal through hetero-tetrameric complexes of type I and type II …
family (TGFβ), which signal through hetero-tetrameric complexes of type I and type II …
[HTML][HTML] BMP signaling in vascular diseases
J Cai, E Pardali, G Sánchez-Duffhues, P ten Dijke - FEBS letters, 2012 - Elsevier
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-
β) family that signal via type I and type II serine/threonine kinase receptors and intracellular …
β) family that signal via type I and type II serine/threonine kinase receptors and intracellular …
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification
D Dey, J Bagarova, SJ Hatsell, KA Armstrong… - Science translational …, 2016 - science.org
Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO)
syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I …
syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I …
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia
HT Lindholm, N Parmar, C Drurey… - Science …, 2022 - science.org
The intestinal tract is a common site for various types of infections including viruses,
bacteria, and helminths, each requiring specific modes of immune defense. The intestinal …
bacteria, and helminths, each requiring specific modes of immune defense. The intestinal …
Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
K Hino, K Horigome, M Nishio… - The Journal of …, 2017 - Am Soc Clin Investig
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized
by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor …
by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor …
BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics
C Hiepen, J Jatzlau, S Hildebrandt, B Kampfrath… - PLoS …, 2019 - journals.plos.org
Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-
signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is …
signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is …
[HTML][HTML] Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors
G Sanchez-Duffhues, E Williams, MJ Goumans… - Bone, 2020 - Elsevier
Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and
function of many different cell types. They exert their cellular responses via heteromeric …
function of many different cell types. They exert their cellular responses via heteromeric …
Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils
Y Kimishima, T Misaka, T Yokokawa, K Wada… - Nature …, 2021 - nature.com
Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by
pulmonary arterial remodeling. Clonal somatic mutations including JAK2 V617F, the most …
pulmonary arterial remodeling. Clonal somatic mutations including JAK2 V617F, the most …