Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological
processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is …

This paper reviews the body of evidence that not only tryptophan and consequent 5-HT
depletion, but also induction of indoleamine 2, 3-dioxygenase (IDO) and the detrimental …

Dysregulated kynurenine (KYN) pathway has been implicated in the pathophysiology of
depression. In this systematic review, we examined the relationship between kynurenine …

Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

Chronic hepatitis C (CHC) affects over 170 million individuals worldwide and is a growing
public health concern. Despite the availability of CHC treatment, specifically interferon‐α …

OBJECTIVE: The aim of the pre-sent study was to investigate the effect of the serotonin
selective reuptake inhibitors (SSRIs) fluoxetine and sertraline and the tricyclic drug …

Objective: To assess the utility of prophylactic administration of antidepressants in
preventing a major depressive episode during antiviral treatment for chronic hepatitis C …

Objective: The prevalence of hepatitis C virus (HCV) infection in Canada is estimated to be
1% and expected to increase during the next decade. Mental illness, particularly depression …

Abstract Hepatitis C Virus (HCV) is a major health problem, infecting about 3% of people
worldwide and leading to liver as well as extrahepatic diseases. This justifies the definition …

Sleep disturbances occur in up to 60% of patients with chronic hepatitis C (CHC) and is
often interrelated with comorbid psychiatric disorders. Moreover, neuropsychiatric …