Posttranslational control of HuR function

I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

HuR as a molecular target for cancer therapeutics and immune-related disorders

M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

[HTML][HTML] Post-translational control of RNA-binding proteins and disease-related dysregulation

A Velázquez-Cruz, B Baños-Jaime… - Frontiers in molecular …, 2021 - frontiersin.org
Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

[HTML][HTML] From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

S Ebeling, K Naumann, S Pollok, T Wardecki… - Plos one, 2014 - journals.plos.org
Background Birch bark has a long lasting history as a traditional medicinal remedy to
accelerate wound healing. Recently, the efficacy of birch bark preparations has also been …

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer …

FF Blanco, M Jimbo, J Wulfkuhle, I Gallagher, J Deng… - Oncogene, 2016 - nature.com
Previously, it has been shown that pancreatic ductal adenocarcinoma (PDA) tumors exhibit
high levels of hypoxia, characterized by low oxygen pressure (pO 2) and decreased O 2 …

[HTML][HTML] Drug delivery approaches for HuR-targeted therapy for lung cancer

R Raguraman, S Shanmugarama, M Mehta… - Advanced drug delivery …, 2022 - Elsevier
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …

The p38-MK2-HuR pathway potentiates EGFRvIII–IL-1β-driven IL-6 secretion in glioblastoma cells

FMS Gurgis, YT Yeung, MXM Tang, B Heng… - Oncogene, 2015 - nature.com
The microenvironment of glioblastoma (GBM) contains high levels of inflammatory cytokine
interleukin 6 (IL-6), which contributes to promote tumour progression and invasion. The …

[HTML][HTML] Hu antigen R (HuR) protein structure, function and regulation in hepatobiliary tumors

S Lachiondo-Ortega, TC Delgado, B Baños-Jaime… - Cancers, 2022 - mdpi.com
Simple Summary Hepatobiliary tumors are a group of primary malignancies encompassing
the liver, the intra-and extra-hepatic biliary tracts, and the gall bladder. Within the liver …

[HTML][HTML] A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus

C Yuan, WL Smith - Journal of Biological Chemistry, 2015 - ASBMB
Cyclooxygenases (COXs) catalyze the committed step in prostaglandin (PG) biosynthesis.
COX-1 is constitutively expressed and stable, whereas COX-2 is inducible and short lived …

[HTML][HTML] ELAVL1 role in cell fusion and tunneling membrane nanotube formations with implication to treat glioma heterogeneity

N Filippova, LB Nabors - Cancers, 2020 - mdpi.com
Simple Summary Despite the numerous novel pharmacological and immunological
approaches for multimodal glioma treatments that have been proposed in recent years …