Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The
functional components are the protective mucous layer, the airway surface liquid layer, and …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

In addition to the classical neurotransmitters, acetylcholine and noradrenaline, a wide
number of peptides with neurotransmitter activity have been identified in the past few years …

Release of neuropeptides, including tachykinins and calcitonin gene-related peptide, from
sensory nerves via an axon or local reflex may have inflammatory effects in the airways. This …

Lung research supported by the National Heart, Lung, and Blood Institute (NHLBI) has had
important outcomes that have resulted in an infinitely better understanding of how …

The aim of this investigation was to identify the proportional neurochemical codes of enteric
neurons and to determine the specific terminal fields of chemically defined nerve fibers in all …

Most airway mucus is produced by submucosal glands in response to neural signals. Gland
mucus traps microbes, inhibits their replication, and clears them from the airways. In cystic …

Neurogenic inflammation encompasses the release of neuropeptides from airway nerves
leading to inflammatory effects. This neurogenic inflammatory response of the airways can …

Although alteration of airway pH may serve an innate host defense capacity, it also is
implicated in the pathophysiology of obstructive airway diseases. Acid-induced asthma …

The sensory neuropeptides substance P (SP) and neurokinin A (NKA) are localized to
sensory airway nerves, from which they can be released by a variety of stimuli, including …