T-cell receptor repertoire sequencing and its applications: focus on infectious diseases and cancer

L Mazzotti, A Gaimari, S Bravaccini, R Maltoni… - International journal of …, 2022 - mdpi.com
The immune system is a dynamic feature of each individual and a footprint of our unique
internal and external exposures. Indeed, the type and level of exposure to physical and …

Studying T cell responses to hepatotropic viruses in the liver microenvironment

J Lopez-Scarim, SM Nambiar, E Billerbeck - Vaccines, 2023 - mdpi.com
T cells play an important role in the clearance of hepatotropic viruses but may also cause
liver injury and contribute to disease progression in chronic hepatitis B and C virus infections …

T-Cell Exhaustion in HIV-1/Hepatitis C Virus Coinfection Is Reduced After Successful Treatment of Chronic Hepatitis C

K Caraballo Cortés, S Osuch… - Open Forum …, 2023 - academic.oup.com
Background T-cell responses during chronic viral infections become exhausted, which is
reflected by upregulation of inhibitory receptors (iRs) and increased interleukin 10 (IL-10) …

Double Positive CD4+CD8+ (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C

AM Kochanowicz, S Osuch, H Berak, A Kumorek… - Cells, 2023 - mdpi.com
In chronic hepatitis C (CHC), characterized by exhaustion of T-cell function, increased
frequencies of double-positive (DP)(CD4+ CD8+) cells are present in peripheral blood. We …

[PDF][PDF] Double Positive CD4+CD8+(DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C. Cells 2023, 12, 1446

AM Kochanowicz, S Osuch, H Berak, A Kumorek… - 2023 - ppm.wum.edu.pl
In chronic hepatitis C (CHC), characterized by exhaustion of T-cell function, increased
frequencies of double-positive (DP)(CD4+CD8+) cells are present in peripheral blood. We …