[HTML][HTML] The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis

W Chen, J Xu, Y Wu, B Liang, M Yan… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central
role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK …

Chagas disease: a silent threat for dogs and humans

J Durães-Oliveira, J Palma-Marques, C Moreno… - International Journal of …, 2024 - mdpi.com
Chagas disease (CD) is a vector-borne Neglected Zoonotic Disease (NZD) caused by a
flagellate protozoan, Trypanosoma cruzi, that affects various mammalian species across …

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

AM Padilla, W Wang, T Akama, DS Carter… - Nature …, 2022 - nature.com
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people,
primarily in Latin America, causing morbidity and mortality. The options for treatment and …

Metallic nanoparticles and core-shell nanosystems in the treatment, diagnosis, and prevention of parasitic diseases

G Król, K Fortunka, M Majchrzak, E Piktel, P Paprocka… - Pathogens, 2023 - mdpi.com
The usage of nanotechnology in the fight against parasitic diseases is in the early stages of
development, but it brings hopes that this new field will provide a solution to target the early …

Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches

LFA Fiuza, DGJ Batista, RD Girão, F Hulpia… - Molecules, 2022 - mdpi.com
Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem.
Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious …

1, 3-Thiazole derivatives as privileged structures for anti-Trypanosoma cruzi activity: Rational design, synthesis, in silico and in vitro studies

MCH de Barros Dias, MS Barbalho… - European Journal of …, 2023 - Elsevier
Chagas disease is a deadly and centenary neglected disease that is recently surging as a
potential global threat. Approximately 30% of infected individuals develop chronic Chagas …

Antimicrobial peptides (AMPs): potential therapeutic strategy against trypanosomiases?

M Rojas-Pirela, U Kemmerling, W Quiñones… - Biomolecules, 2023 - mdpi.com
Trypanosomiases are a group of tropical diseases that have devastating health and socio-
economic effects worldwide. In humans, these diseases are caused by the pathogenic …

3′-Demethoxy-6-O-Demethylisoguaiacin and Norisoguaiacin Nematocidal Lignans from Artemisia cina against Haemonchus contortus Infective Larvae

RI Higuera-Piedrahita, M Dolores-Hernández… - Plants, 2023 - mdpi.com
Artemisia cina is a plant used in traditional Chinese medicine as a remedy for parasitic
diseases. This study describes the isolation and chemical characterization of anthelmintic …

Organometallic N‐acylhydrazones of 5‐nitrofuran and 5‐nitrothiophene based: Synthesis, electrochemical, antiparasitic evaluation, and computational study

M Saldías, A Acuña, M Mellado… - Applied …, 2023 - Wiley Online Library
In searching for new therapeutic agents for treating American trypanosomiasis and Human
African trypanosomiasis, four nitroheterocyclic acylhydrazones of general formulae [R1‐CH …

Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells

JMC Barbosa, Y Pedra-Rezende, LD Pereira… - Frontiers in Cellular …, 2022 - frontiersin.org
Chagas disease (CD), a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi, is an important public health problem mainly in Latin America, leading …