Optical biosensors that exploit surface plasmon resonance, waveguides and resonant
mirrors have been used widely over the past decade to analyse biomolecular interactions …

The influence of a xenobiotic compound on an organism is usually summarized by the
expression biological activity. If a controlled, therapeutically relevant, and regulatory action …

The number and diversity of surface plasmon resonance (SPR) biosensor applications
continue to increase. Evolutions in instrument and sensor chip technology, experimental …

Objective To evaluate the efficacy and safety of anakinra in combination with methotrexate
(MTX) in patients with active rheumatoid arthritis (RA). Methods Patients with moderate‐to …

The majority of techniques currently employed to interrogate a biomolecular interaction
require some type of radio-or enzymatic-or fluorescent-labelling to report the binding event …

With the introduction of new instruments and improved sensor chip chemistries, surface
plasmon resonance (SPR) is finding new applications for molecular interaction studies. Easy …

The binding interactions of small molecules with carbonic anhydrase II were used as model
systems to compare the reaction constants determined from surface‐and solution‐based …

Surface plasmon resonance (SPR) allows for the investigation of the functional nature of
binding interactions and provides detailed kinetic information across a wide range of …

During the last decade there has been significant progress in the development of analytical
techniques for the screening of ligand binding to membranes and membrane receptors. This …

Direct measurement of the thermodynamics of biomolecular interactions is now relatively
easy. Interpretation of these thermodynamics in simple molecular terms is not. Recent work …