Ferroptotic therapy in cancer: benefits, side effects, and risks
Ferroptosis is a type of regulated cell death characterized by iron accumulation and
uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular …
uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular …
[PDF][PDF] Ferroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …
peroxidation, is governed by molecular networks involving diverse molecules and …
Aging and cancer
Aging and cancer exhibit apparent links that we will examine in this review. The null
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …
[HTML][HTML] Protein modification and degradation in ferroptosis
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox
system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins …
system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins …
Extracellular NCOA4 is a mediator of septic death by activating the AGER-NFKB pathway
J Liu, Y Wang, L Zeng, C Yu, R Kang, DJ Klionsky… - Autophagy, 2024 - Taylor & Francis
Sepsis, a life-threatening condition resulting from a dysregulated response to pathogen
infection, poses a significant challenge in clinical management. Here, we report a novel role …
infection, poses a significant challenge in clinical management. Here, we report a novel role …
Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges
Abstract Selenoprotein glutathione peroxidase 4 (GPX4) serves as a crucial suppressor of
oxidative stress-induced ferroptosis, making it an attractive target for disease therapy. Here …
oxidative stress-induced ferroptosis, making it an attractive target for disease therapy. Here …
Ciprofloxacin is a novel anti-ferroptotic antibiotic
Cancer patients undergoing chemotherapy are susceptible to various bacterial infections,
necessitating prompt and precise antimicrobial treatment with antibiotics. Ciprofloxacin is a …
necessitating prompt and precise antimicrobial treatment with antibiotics. Ciprofloxacin is a …
In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy …
P Lenzi, G Lazzeri, M Ferrucci, CL Busceti… - Journal of Neural …, 2024 - Springer
Neurodegenerative disorders are typically featured by the occurrence of neuronal
inclusions. In the case of Parkinson's disease (PD) these correspond to Lewy bodies (LBs) …
inclusions. In the case of Parkinson's disease (PD) these correspond to Lewy bodies (LBs) …
Sperm freezing damage: the role of regulated cell death
E Hai, B Li, J Zhang, J Zhang - Cell Death Discovery, 2024 - nature.com
Substantial progress in research on sperm cryopreservation has occurred since the
twentieth century, especially focusing on improving sperm freezing procedures and …
twentieth century, especially focusing on improving sperm freezing procedures and …
Mutations in EPG5 are associated with a wide spectrum of neurodevelopmental and neurodegenerative disorders
HS Dafsari, C Deneubourg, K Singh, R Maroofian… - medRxiv, 2024 - medrxiv.org
Autophagy is a fundamental and evolutionary conserved biological pathway with vital roles
in intracellular quality control and homeostasis. The process of autophagy involves the …
in intracellular quality control and homeostasis. The process of autophagy involves the …