There exist limited data to inform mechanism-based understanding and management of
chronic pain, and thus, there is a clear unmet need to better define the molecular …

Modulation of nociception allows animals to optimize chances of survival by adapting their
behaviour in different contexts. In mammals, this is executed by neurons from the brain and …

Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

Pain and itch are two closely related but essentially distinct sensations that elicit different
behavioral responses. However, it remains mysterious how pain and itch information is …

Artificial intelligence (AI) is often used to describe the automation of complex tasks that we
would attribute intelligence to. Machine learning (ML) is commonly understood as a set of …

Human epidemiological studies suggest that chronic pain can increase mortality risk. We
investigated whether this was true in mice so that underlying mechanisms might be …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Abstract Background Complex Regional Pain Syndrome (CRPS) leads to a debilitating
chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely …

The lack of sensitive and robust behavioral assessments of pain in preclinical models has
been a major limitation for both pain research and the development of novel analgesics …

Around 20% of the American population have chronic pain and estimates in other Western
countries report similar numbers. This represents a major challenge for global health care …