Prematurity, especially preterm birth (less than 32 weeks' gestation), is common and
associated with high rates of both survival and neurodevelopmental disability, especially …

Modern health care has brought our society innumerable benefits but has also introduced
the experience of pain very early in life. For example, it is now routine care for newborns to …

Preterm infants are exposed to frequent painful procedures and agitating stimuli over the
many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse …

Pain experienced during neonatal intensive care management can influence
neurodevelopmental outcome and the somatosensory and/or emotional components of pain …

Background Pain in the neonate is associated with acute behavioural and physiological
changes. Cumulative pain is associated with morbidities, including adverse …

The third trimester of pregnancy represents a sensitive phase for infant brain plasticity when
a series of fast-developing cellular events (synaptogenesis, neuronal migration, and …

Altered hippocampal morphology and reduced volumes have been found in children born
preterm compared to full-term. Stress inhibits neurogenesis in the hippocampus, and …

The prevention, assessment, and treatment of neonatal pain and agitation continues to
challenge clinicians and researchers. Substantial progress has been made in the past three …

The American Academy of Pediatrics'(AAP) recommendations for “Routine neuroimaging of
the preterm brain” focuses on cranial ultrasound (cUS) screening, initially for the diagnosis …

Despite the advances in neonatal intensive care, the preterm brain remains vulnerable to
white matter injury (WMI) and disruption of normal brain development (ie, dysmaturation) …