Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …

A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …

Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell
membranes. Here we report the development of a Salmonella-based intracellular delivery …

Pyroptosis is a form of programmed cell death, and recently described as a new molecular
mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Hepatocellular carcinoma (HCC) is swiftly increasing in prevalence globally with a high
mortality rate. The progression of HCC in patients is induced with advanced fibrosis, mainly …

Introduction: The MAPK pathway comprises several key signaling components and
phosphorylation events that play a role in tumorigenesis. These activated kinases transmit …

Background Annotations of the phylogenetic tree of the human kinome is an intuitive way to
visualize compound profiling data, structural features of kinases or functional relationships …