[HTML][HTML] Inositol polyphosphate multikinase signaling: multifaceted functions in health and disease
B Lee, SJ Park, S Hong, K Kim, S Kim - Molecules and cells, 2021 - Elsevier
Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes
from yeasts to mammals, which are synthesized by a complex network of enzymes including …
from yeasts to mammals, which are synthesized by a complex network of enzymes including …
Targeting the tumor immune microenvironment with “nutraceuticals”: From bench to clinical trials
L Masuelli, M Benvenuto, C Focaccetti, S Ciuffa… - Pharmacology & …, 2021 - Elsevier
The occurrence of immune effector cells in the tissue microenvironment during neoplastic
progression is critical in determining tumor growth outcomes. On the other hand, tumors may …
progression is critical in determining tumor growth outcomes. On the other hand, tumors may …
Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia
Introduction Preeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset
hypertension and proteinuria and it is often associated with fetal intrauterine growth …
hypertension and proteinuria and it is often associated with fetal intrauterine growth …
Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+ influx
Activated Foxp3+ regulatory T (Treg) cells differentiate into effector Treg (eTreg) cells to
maintain peripheral immune homeostasis and tolerance. T cell receptor (TCR)–mediated …
maintain peripheral immune homeostasis and tolerance. T cell receptor (TCR)–mediated …
miRNA-induced downregulation of IPMK in macrophages mediates lipopolysaccharide-triggered TLR4 signaling
Inositol polyphosphate multikinase (IPMK) is a pleiotropic enzyme responsible for the
production of inositol polyphosphates and phosphoinositide. IPMK in macrophages was …
production of inositol polyphosphates and phosphoinositide. IPMK in macrophages was …
Myo-Inositol Restores Tilapia's Ability Against Infection by Aeromonas sobria in Higher Water Temperature
M Yang, M Jiang, X Peng, H Li - Frontiers in Immunology, 2021 - frontiersin.org
Bacterial infection presents severe challenge to tilapia farming, which is largely influenced
by water temperature. However, how water temperature determines tilapias' survival to …
by water temperature. However, how water temperature determines tilapias' survival to …
Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
Abstract The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec
homology (PH-TH) module connected by a proline-rich linker to a 'Src module', an SH3-SH2 …
homology (PH-TH) module connected by a proline-rich linker to a 'Src module', an SH3-SH2 …
Pharmacological tools to investigate inositol polyphosphate kinases–enzymes of increasing therapeutic relevance
T Kröber, SM Bartsch, D Fiedler - Advances in Biological Regulation, 2022 - Elsevier
Inositol poly-and pyrophosphates (InsPs and PP-InsPs) are a group of central eukaryotic
metabolites and signaling molecules. Due to the diverse cellular functions and widespread …
metabolites and signaling molecules. Due to the diverse cellular functions and widespread …
[HTML][HTML] Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis
S Furuta - Cancers, 2024 - mdpi.com
Simple Summary It has long been known that breast tumors harbor various types of
microbes. However, it was little known where these tumor-resident microbes came from and …
microbes. However, it was little known where these tumor-resident microbes came from and …