Drugging membrane protein interactions
H Yin, AD Flynn - Annual review of biomedical engineering, 2016 - annualreviews.org
The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …
The function, structure, and origins of the ER membrane protein complex
RS Hegde - Annual Review of Biochemistry, 2022 - annualreviews.org
The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …
Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
Endothelial responses to fluid shear stress are essential for vascular development and
physiology, and determine the formation of atherosclerotic plaques at regions of disturbed …
physiology, and determine the formation of atherosclerotic plaques at regions of disturbed …
De novo design of a transmembrane Zn2+-transporting four-helix bundle
The design of functional membrane proteins from first principles represents a grand
challenge in chemistry and structural biology. Here, we report the design of a membrane …
challenge in chemistry and structural biology. Here, we report the design of a membrane …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
[图书][B] Introduction to proteins: structure, function, and motion
Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
FTIR-based spectrum of salivary exosomes coupled with computational-aided discriminating analysis in the diagnosis of oral cancer
A Zlotogorski-Hurvitz, BZ Dekel, D Malonek… - Journal of cancer …, 2019 - Springer
Abstract Purpose To determine the Fourier-transform infrared (FTIR) spectra of salivary
exosomes from oral cancer (OC) patients and healthy individuals (HI) and to assess its …
exosomes from oral cancer (OC) patients and healthy individuals (HI) and to assess its …
The biogenesis of multipass membrane proteins
L Smalinskaitė, RS Hegde - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Multipass membrane proteins contain two or more α-helical transmembrane domains
(TMDs) that span the lipid bilayer. They are inserted cotranslationally into the prokaryotic …
(TMDs) that span the lipid bilayer. They are inserted cotranslationally into the prokaryotic …
Hepatitis C virus RNA replication
V Lohmann - Hepatitis C virus: from molecular virology to antiviral …, 2013 - Springer
Genome replication is a crucial step in the life cycle of any virus. HCV is a positive strand
RNA virus and requires a set of nonstructural proteins (NS3, 4A, 4B, 5A, and 5B) as well as …
RNA virus and requires a set of nonstructural proteins (NS3, 4A, 4B, 5A, and 5B) as well as …
The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes
M Löwe, M Kalacheva, AJ Boersma… - The FEBS …, 2020 - Wiley Online Library
Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …
packed within the limited surface area, proteins fulfil essential tasks for life, which include …