Challenges and opportunities in translational pain research–An opinion paper of the working group on translational pain research of the European pain federation …
For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …
to translate into efficacious treatments for patients with pain. Despite great improvement in …
DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation
LQ Zhang, SJ Gao, J Sun, DY Li, JY Wu… - Journal of …, 2022 - Springer
Background Neuropathic pain is a common and severely disabling state that affects millions
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …
Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research
N Su, P Cai, Z Dou, X Yin, H Xu, J He, Z Li… - Frontiers in …, 2023 - frontiersin.org
Neuropathic pain (NP) is known to be associated with abnormal changes in specific brain
regions, but the complex neural network behind it is vast and complex and lacks a …
regions, but the complex neural network behind it is vast and complex and lacks a …
[HTML][HTML] Activation of the dorsal, but not the ventral, hippocampus relieves neuropathic pain in rodents
X Wei, MV Centeno, W Ren, AM Borruto, D Procissi… - Pain, 2021 - journals.lww.com
Accumulating evidence suggests hippocampal impairment under the chronic pain
phenotype. However, it is unknown whether neuropathic behaviors are related to …
phenotype. However, it is unknown whether neuropathic behaviors are related to …
High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain
K Hisaoka-Nakashima, K Ohata, N Yoshimoto… - Experimental …, 2022 - Elsevier
Clinical evidence indicates that cognitive impairment is a common comorbidity of chronic
pain, including neuropathic pain, but the mechanism underlying cognitive impairment …
pain, including neuropathic pain, but the mechanism underlying cognitive impairment …
Scfas ameliorate chronic postsurgical pain–related cognition dysfunction via the ACSS2-HDAC2 axis in rats
Z Li, T Sun, Z He, Z Li, W Zhang, J Wang… - Molecular …, 2022 - Springer
Patients with chronic postsurgical pain (CPSP) frequently exhibit comorbid cognitive deficits.
Recent observations have emphasized the critical effects of gut microbial metabolites, like …
Recent observations have emphasized the critical effects of gut microbial metabolites, like …
GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-κB pathway in neuropathic pain mice
LQ Zhang, W Zhang, T Li, T Yang, X Yuan… - … of Learning and …, 2021 - Elsevier
Growing evidences indicate that neuropathic pain is frequently accompanied with cognitive
impairments, which aggravate the decrease in the quality of life of chronic pain patients …
impairments, which aggravate the decrease in the quality of life of chronic pain patients …
[HTML][HTML] PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus
X Liu, Z Xie, S Li, J He, S Cao, Z Xiao - International journal of …, 2021 - ncbi.nlm.nih.gov
Rationale: Pain and depression, which tend to occur simultaneously and share some
common neural circuits and neurotransmitters, are highly prevalent complication in patients …
common neural circuits and neurotransmitters, are highly prevalent complication in patients …
Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in …
L Chen, N Yang, Y Li, Y Li, J Hong… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims Delayed neurocognitive recovery (dNCR) is a common postoperative complication in
geriatric surgical patients for which there is no efficacious therapy. Cholecystokinin …
geriatric surgical patients for which there is no efficacious therapy. Cholecystokinin …
5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation
LQ Zhang, YQ Zhou, JY Li, J Sun, S Zhang… - Frontiers in …, 2022 - frontiersin.org
Neuropathic pain is a devastating disease that affects millions of people worldwide.
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …