Circulating extracellular vesicles as biomarkers and drug delivery vehicles in cardiovascular diseases

RCC de Freitas, RDC Hirata, MH Hirata, E Aikawa - Biomolecules, 2021 - mdpi.com
Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane and
soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles) …

Recent advances of using exosomes as diagnostic markers and targeting carriers for cardiovascular disease

N Li, T Zhang, L Zhu, L Sun, G Shao… - Molecular …, 2023 - ACS Publications
Cardiovascular diseases (CVDs) are the leading cause of human death worldwide.
Exosomes act as endogenous biological vectors; they possess advantages of low …

[HTML][HTML] Identification and mechanistic study of four novel ACE inhibitory peptides from maize germ protein hydrolysates

K Liu, Z Gao, Q Li, H Zhang - LWT, 2023 - Elsevier
Nowadays, much exertion has been given to identifying angiotensin-I converting enzyme
inhibitory peptides (ACEIPs) from food by-products, while little attention has been paid to …

Soybean-derived antihypertensive peptide LSW (Leu–Ser–Trp) antagonizes the damage of angiotensin II to vascular endothelial cells through the trans-vesicular …

T Song, M Lv, M Zhou, M Huang… - Journal of Agricultural …, 2021 - ACS Publications
An emerging inference is that vascular cells transfer their biological cargo to recipient cells
by secretion of extracellular vesicles (EVs). This study explored the effects of EVs produced …

The anti-inflammatory effect of vasoactive peptides from soybean protein hydrolysates by mediating serum extracellular vesicles-derived miRNA-19b/CYLD/TRAF6 …

T Song, M Zhou, W Li, M Lv, L Zheng, M Zhao - Food Research International, 2022 - Elsevier
The excessive accumulation of angiotensin II (Ang II) in the vascular microenvironment
promotes vascular dysfunction including vascular endothelial inflammation and remodeling …

A novel angiotensin I-converting enzyme inhibitory peptide derived from goat milk casein hydrolysate modulates angiotensin II-stimulated effects on vascular smooth …

Z Qiao, J Wang, Z He, L Pan, K Feng, X Peng… - Frontiers in …, 2022 - frontiersin.org
Hypertension is a major risk factor leading to cardiovascular disease, and is frequently
treated with angiotensin I-converting enzyme (ACE) inhibitory peptides. The objective of this …

The protective effects of tripeptides VPP and IPP against small extracellular vesicles from angiotensin II-induced vascular smooth muscle cells mediating endothelial …

T Song, M Lv, L Zhang, X Zhang, G Song… - Journal of Agricultural …, 2020 - ACS Publications
Endothelial dysfunction is a common disorder of vascular homeostasis in hypertension
characterized by oxidative stress, malignant migration, inflammatory response, and active …

A novel angiotensin I-converting enzyme inhibitory peptide APPLRP from Grifola frondosa ameliorated the Ang II-induced vascular modeling in zebrafish model by …

T Song, T Zhang, Q Cai, YY Ding, Z Gu - International Journal of Biological …, 2024 - Elsevier
Grifola frondosa has garnered significant popularity as an edible mushroom attributable to
its exceptional taste and nutritional benefits. This study isolated APPLRP, a potent ACE …

[HTML][HTML] An ACE-inhibitory peptide derived from maize germ antagonizes the Angiotensin II-induced dysfunction of HUVECs via the PI3K/Akt/eNOS signaling pathway

Q Li, K Liu, Z Gao, MT Rashid - Journal of Functional Foods, 2024 - Elsevier
Our previous work identified an ACE inhibitory peptide (ACEIP) with a sequence of LPGP
from maize germ protein. In this study, by employing Ang II-induced Human Umbilical Vein …

Oral Administration of Fermented Milk from Co-Starter Containing Lactobacillus plantarum Y44 Shows an Ameliorating Effect on Hypertension in Spontaneously …

J Yu, M Sun, S Jiang, C Jiang, G Mu, Y Tuo - Foods, 2024 - mdpi.com
Fermented dairy foods such as yogurt exhibit some beneficial effects on consumers,
including relieving the symptoms of hypertension. This study aims to obtain fermented dairy …