Investigating epithelial‐mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modeling

F Bocci, S Mandal, T Tejaswi… - … and Systems Oncology, 2021 - Wiley Online Library
Cellular heterogeneity along the epithelial‐mesenchymal plasticity (EMP) spectrum is a
paramount feature observed in tumors and circulating tumor cells (CTCs). High‐throughput …

Agent‐based modelling reveals strategies to reduce the fitness and metastatic potential of circulating tumour cell clusters

M Campenni, AN May, A Boddy, V Harris… - Evolutionary …, 2020 - Wiley Online Library
Metastasis—the ability of cancer cells to disperse throughout the body and establish new
tumours at distant locations—is responsible for most cancer‐related deaths. Although both …

[图书][B] Gravity Microfiltration for Enriching Circulating Tumour Cells and Clusters

N Chahley - 2022 - search.proquest.com
Cancer is a leading cause of death worldwide, and metastatic lesions the primary mortal
complication in solid tumour cancers. Tumour characterization by tissue biopsy is an …

An Evolutionary Perspective on Neoplastic Disease Across the Tree of Life

VK Harris - 2022 - search.proquest.com
Cancer is a disease of multicellularity, with deep evolutionary origins. As such, the forces of
both evolution and natural selection operate on multiple scales to govern tumor dynamics …