Background Studies on and the application of polyphenolic compounds, have recently
attracted great interest in the functional foods due to their potential health benefits to …

Pancreatic islet β cells secrete insulin in response to nutrient secretagogues, like glucose,
dependent on calcium influx and nutrient metabolism. One of the most intriguing qualities of …

Recently developed ketone (monoester or salt) supplements acutely elevate blood β-
hydroxybutyrate (BHB) exogenously without prolonged periods of fasting or carbohydrate …

Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a
narrow range. Defects in the function and mass of β-cells play a significant role in the …

Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …

The construction of a predictive model of an entire eukaryotic cell that describes its dynamic
structure from atomic to cellular scales is a grand challenge at the intersection of biology …

At present, the importance of triterpenes in food and pharmaceutical industries is mainly
based on their potential application in health food and medicine, particularly those …

Signaling networks are spatiotemporally organized in order to sense diverse inputs, process
information, and carry out specific cellular tasks. In pancreatic β cells, Ca 2+, cyclic …

Background The potential of a ketone monoester (β-hydroxybutyrate; KEβHB) supplement to
rapidly mimic a state of nutritional ketosis offers a new therapeutic possibility for diabetes …

Over the past century, since the discovery of insulin, the therapeutic offer for diabetes has
grown exponentially, in particular for type 2 diabetes (T2D). However, the drugs in the …