As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

The ubiquitin proteasome pathway is responsible for most of the protein degradation in
mammalian cells. Rates of degradation by this pathway have generally been assumed to be …

Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Quantitative mass spectrometry has established proteome-wide regulation of protein
abundance and post-translational modifications in various biological processes. Here, we …

Recently, many studies have been conducted trying to explain the molecular mechanism of
curcumin action in various pathological states of the cell and the organism. Curcumin is …

Tauopathies are neurodegenerative diseases characterized by the pathological
accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary …

Curcumin, the active ingredient in Curcuma longa, has been in medicinal use since ancient
times. However, the therapeutic targets and signaling cascades modulated by curcumin …

Intracellular proteins continuously turn over by degradation and synthesis in all organ
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …