Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease

Y Ma, G Lee, SY Heo, YS Roh - Antioxidants, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload

R Harjumäki, CS Pridgeon… - International Journal of …, 2021 - mdpi.com
CYP2E1 is one of the fifty-seven cytochrome P450 genes in the human genome and is
highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively …

Associations between dietary flavonoid intake with hepatic steatosis and fibrosis quantified by VCTE: evidence from NHANES and FNDDS

R Xie, Y Zhang - Nutrition, Metabolism and Cardiovascular Diseases, 2023 - Elsevier
Background and aim Flavonoids are natural products of plant origin and have been shown
to be beneficial for nonalcoholic fatty liver disease (NAFLD) in animal studies. However …

Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress

P Gong, H Long, Y Guo, Z Wang, W Yao, J Wang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Plants are a natural treasure trove; their secondary
metabolites participate in several pharmacological processes, making them a crucial …

Natural polyphenols in metabolic syndrome: protective mechanisms and clinical applications

S Zhang, M Xu, W Zhang, C Liu, S Chen - International journal of …, 2021 - mdpi.com
Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia,
hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely …

The polyphenolic profile and antioxidant activity of five vegetal extracts with hepatoprotective potential

L Costea, CL Chițescu, R Boscencu, M Ghica… - Plants, 2022 - mdpi.com
Oxidative stress is among the major triggers for many important human functional disorders,
which often lead to various metabolic or tissue diseases. The aim of the study is to obtain …

USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1

D Wei, X Tian, L Zhu, H Wang, C Sun - Cell Death & Disease, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) begins with excessive triglyceride accumulation in
the liver, and overly severe hepatic steatosis progresses to nonalcoholic steatohepatitis …

[HTML][HTML] The great potential of flavonoids as candidate drugs for NAFLD

L Li, Y Qin, X Xin, S Wang, Z Liu, X Feng - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of approximately 25%
and is associated with high morbidity and high mortality. NAFLD is a leading cause of …

In a prediabetic model, empagliflozin improves hepatic lipid metabolism independently of obesity and before onset of hyperglycemia

M Hüttl, I Markova, D Miklankova, I Zapletalova… - International journal of …, 2021 - mdpi.com
Recent studies suggest that treatment with SGLT-2 inhibitors can reduce hepatic lipid
storage and ameliorate non-alcoholic fatty liver disease (NAFLD) development beyond their …

Sequentially fermented dealcoholized apple juice intervenes fatty liver induced by high-fat diets via modulation of intestinal flora and gene pathways

H Li, J Liang, M Han, X Wang, Y Ren, Y Wang… - Food Research …, 2022 - Elsevier
Low-alcohol beverages damage the liver, whereas dealcoholized apple juice sequentially
fermented by Saccharomyces cerevisiae and Lactobacillus plantarum is a promising dietary …