5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

S Vodenkova, T Buchler, K Cervena… - Pharmacology & …, 2020 - Elsevier
Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …

Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

SR Lin, CH Chang, CF Hsu, MJ Tsai… - British journal of …, 2020 - Wiley Online Library
Traditional chemotherapy is being considered due to hindrances caused by systemic
toxicity. Currently, the administration of multiple chemotherapeutic drugs with different …

Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro

R Wadhwa, KR Paudel, LH Chin… - Journal of food …, 2021 - Wiley Online Library
In this study, we had developed Naringenin‐loaded liquid crystalline nanoparticles (LCNs)
and investigated the anti‐inflammatory and anticancer activities of Naringenin‐LCNs against …

[HTML][HTML] Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance

PB Gupta, I Pastushenko, A Skibinski, C Blanpain… - Cell stem cell, 2019 - cell.com
Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …

Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy

Z Yu, H Tang, S Chen, Y Xie, L Shi, S Xia… - Drug Resistance …, 2023 - Elsevier
Aims This study aims at investigating the role of a neighbor long non-coding RNA (lncRNA)
of HDAC4 (LOC85009) in docetaxel (DTX) resistance of lung adenocarcinoma (LUAD) …

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

MR Ippolito, V Martis, S Martin, AE Tijhuis, C Hong… - Developmental cell, 2021 - cell.com
Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in
cancer cells. Alterations in chromosome copy number induce a wide variety of cellular …

[HTML][HTML] Dihydroartemisinin: a potential natural anticancer drug

X Dai, X Zhang, W Chen, Y Chen, Q Zhang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs),
and it is an effective clinical drug widely used to treat malaria. Recently, the anticancer …

The role of tumor microenvironment in chemoresistance: to survive, keep your enemies closer

DA Senthebane, A Rowe, NE Thomford… - International journal of …, 2017 - mdpi.com
Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Nivolumab in combination with platinum‐based doublet chemotherapy for first-line treatment of advanced non–small-cell lung cancer

NA Rizvi, MD Hellmann, JR Brahmer… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Nivolumab, a fully human immunoglobulin G4 programmed death-1 immune
checkpoint inhibitor antibody, has demonstrated improved survival in previously treated …

Cisplatin in the modern era: The backbone of first-line chemotherapy for non-small cell lung cancer

DA Fennell, Y Summers, J Cadranel, T Benepal… - Cancer treatment …, 2016 - Elsevier
The treatment of advanced non-small cell lung cancer (NSCLC) may be changing, but the
cisplatin-based doublet remains the foundation of treatment for the majority of patients with …