Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Significance: Autophagy is a self-degrading process that determines cell fate in response to
various environmental stresses. In contrast to autophagy-mediated cell survival, the signals …

Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation
process that plays a complex role in cellular stress, either promoting survival or triggering …

Although induction of ferroptosis, an iron-dependent form of non-apoptotic cell death, has
emerged as an anticancer strategy, the metabolic basis of ferroptotic death remains poorly …

Ferroptosis is a type of nonapoptotic cell death driven by lipid peroxidation. Here, we show a
key role of MGST1 in inhibiting ferroptosis in cell cultures and mouse xenograft models …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year
survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a …

Ferroptosis is a type of iron-dependent regulated cell death caused by the disruption that
occurs when oxidative stress and antioxidant defenses interact, and then driven by lipid …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …